366 Neonatal cystic fibrosis screening in Russian Federation

Neonatal screening for cystic fibrosis.

Two groups of patients with cystic fibrosis were compared. The screened group, detected with an improved neonatal screening assay for immunoreactive trypsin, developed fewer chest infections requiring treatment and gained more weight than the unscreened group. Early diagnosis by screening seems to affect early morbidity.

Screening in cystic fibrosis

A few trials on prenatal CF carrier screening have been performed assessing what proportion of pregnant women are likely to be offered screening and what proportion are likely to accept the test if it is offered free by their own physician (Rowley PT, 1997; Loader S, 1996). A paucity of experience-database is available on CF carrier screening and to terminate CF affected pregnancies. Women foun...

Cost-effectiveness of 4 neonatal screening strategies for cystic fibrosis.

OBJECTIVES The purpose of this work was to assess the costs of 4 neonatal screening strategies for cystic fibrosis in relation to health effects. In each strategy, the first test was the measurement of serum concentration of immunoreactive trypsin. The second step consisted of either a second immunoreactive trypsin test (strategy 1) or a multiple mutation analysis (strategy 2). In strategies 3 ...

Neonatal screening for cystic fibrosis: present and future.

Despite there being effective tests for detecting cystic fibrosis (CF) using newborn screening blood samples, screening in neonates has not had universal approval because of uncertainty about its benefits. After up to 18 y experience, at a recent conference in Caen several aspects attracted universal agreement. There is still major delay in clinical diagnosis after the onset of symptoms. There ...

Long-term health outcomes of neonatal screening for cystic fibrosis.